Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism.

Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism.

Mutations that decrease insulin-like growth factor (IGF) and growth hormone signaling limit body size and prolong lifespan in mice. In vertebrates, these somatotropic hormones are controlled by the neuroendocrine brain. Hormone-like regulations discovered in nematodes and flies suggest that IGF sign...

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Bibliographic Details
Main Authors: Laurent Kappeler, Carlos De Magalhaes Filho, Joëlle Dupont, Patricia Leneuve, Pascale Cervera, Laurence Périn, Catherine Loudes, Annick Blaise, Rüdiger Klein, Jacques Epelbaum, Yves Le Bouc, Martin Holzenberger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-10-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2573928?pdf=render

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http://europepmc.org/articles/PMC2573928?pdf=render

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