Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism.
Mutations that decrease insulin-like growth factor (IGF) and growth hormone signaling limit body size and prolong lifespan in mice. In vertebrates, these somatotropic hormones are controlled by the neuroendocrine brain. Hormone-like regulations discovered in nematodes and flies suggest that IGF sign...
Main Authors: | Laurent Kappeler, Carlos De Magalhaes Filho, Joëlle Dupont, Patricia Leneuve, Pascale Cervera, Laurence Périn, Catherine Loudes, Annick Blaise, Rüdiger Klein, Jacques Epelbaum, Yves Le Bouc, Martin Holzenberger |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008-10-01
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Series: | PLoS Biology |
Online Access: | http://europepmc.org/articles/PMC2573928?pdf=render |
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