2,3,7,8-Tetrachlorodibenzo-p-dioxin prompted differentiation to CD4+CD8−CD25+ and CD4+CD8+CD25+ Tregs and altered expression of immune-related genes in the thymus of chicken embryos

2,3,7,8-Tetrachlorodibenzo-p-dioxin prompted differentiation to CD4+CD8−CD25+ and CD4+CD8+CD25+ Tregs and altered expression of immune-related genes in the thymus of chicken embryos

The chicken (Gallus gallus), which has three aryl hydrocarbon receptor (AHR) isoforms (ckAHR1, ckAHR2, and ckAHR1β) and two AHR nuclear translocator (ARNT) isoforms (ckARNT1 and ckARNT2), is highly sensitive to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and can serve as an avian model to gain an und...

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Bibliographic Details
Main Authors: Min-Kyung Cho, Jae-Gon Park, Hisato Iwata, Eun-Young Kim
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Aryl hydrocarbon receptor (AHR)
AHR nuclear translocator (ARNT)
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Chicken
Immune system
Thymus
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321000580

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http://www.sciencedirect.com/science/article/pii/S0147651321000580

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