5-Aza-2′-deoxycytidine increases hypoxia tolerance-dependent autophagy in mouse neuronal cells by initiating the TSC1/mTOR pathway

5-Aza-2′-deoxycytidine increases hypoxia tolerance-dependent autophagy in mouse neuronal cells by initiating the TSC1/mTOR pathway

Background: Our previous study found that 5-Aza-2′-deoxycytidine (5-Aza-CdR) can repress the expression and activity of protein serine/threonine phosphatase-1γ (PP1γ) in mouse hippocampus. It is well known that PP1γ regulates cell metabolism, which is related to hypoxia/ischaemia tolerance. It has b...

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Bibliographic Details
Main Authors: Ruifang Qi, Xiaolu Zhang, Yabin Xie, Shuyuan Jiang, You Liu, Xiaolei Liu, Wei Xie, Xiaoe Jia, Rengui Bade, Ruili Shi, Sijie Li, Changhong Ren, Kerui Gong, Chunyang Zhang, Guo Shao
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Autophagy
5-Aza-2′-deoxycytidine
Hypoxia tolerance
TSC1
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219319250

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http://www.sciencedirect.com/science/article/pii/S0753332219319250

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