The mTOR/ULK1 signaling pathway mediates the autophagy-promoting and osteogenic effects of dicalcium silicate nanoparticles

The mTOR/ULK1 signaling pathway mediates the autophagy-promoting and osteogenic effects of dicalcium silicate nanoparticles

Abstract A novel bioactive inorganic material containing silicon, calcium and oxygen, calcium silicate (Ca2SiO4, C2S) with a CaO-SiO2 ingredient, has been identified as a potential candidate for artificial bone. Autophagy has an essential function in adult tissue homoeostasis and tumorigenesis. Howe...

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Bibliographic Details
Main Authors: Wang Ruolan, Chen Liangjiao, Shao Longquan
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Nanobiotechnology
Subjects:
Dicalcium silicate
Osteogenesis
Autophagy
MTOR/ULK1
Online Access:http://link.springer.com/article/10.1186/s12951-020-00663-w

Internet

http://link.springer.com/article/10.1186/s12951-020-00663-w

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