Dynamic inosinome profiles reveal novel patient stratification and gender-specific differences in glioblastoma

Dynamic inosinome profiles reveal novel patient stratification and gender-specific differences in glioblastoma

Abstract Background Adenosine-to-inosine (A-to-I) RNA editing is an essential post-transcriptional mechanism mediated by ADAR enzymes that have been recently associated with cancer. Results Here, we characterize the inosinome signature in normal brain and de novo glioblastoma (GBM) using new metrics...

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Bibliographic Details
Main Authors: Domenico Alessandro Silvestris, Ernesto Picardi, Valeriana Cesarini, Bruno Fosso, Nicolò Mangraviti, Luca Massimi, Maurizio Martini, Graziano Pesole, Franco Locatelli, Angela Gallo
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Genome Biology
Subjects:
RNA editing
ADAR
GBM
RNA-Seq
COG3
Online Access:http://link.springer.com/article/10.1186/s13059-019-1647-x

Internet

http://link.springer.com/article/10.1186/s13059-019-1647-x

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