Vasculitis in a Child With the Hyper-IgM Variant of Ataxia-Telangiectasia

Vasculitis in a Child With the Hyper-IgM Variant of Ataxia-Telangiectasia

A subset of patients with Ataxia-Telangiectasia (A-T) have dramatically reduced levels of IgG, IgA, and IgE with retained or elevated IgM levels. Several reports suggest that these A-T patients with a “hyper-IgM phenotype” (HIgM) suffer more clinical immunologic consequences than other A-T patients....

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Bibliographic Details
Main Authors: Anna K. Meyer, Mindy Banks, Tibor Nadasdy, Jennifer J. Clark, Rui Zheng, Erwin W. Gelfand, Jordan K. Abbott
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pediatrics
Subjects:
ataxia-telangiectasia
primary immunodeficiency
vasculitis
hyper IgM
granuloma
tumor necrosis factor
Online Access:https://www.frontiersin.org/article/10.3389/fped.2019.00390/full

Internet

https://www.frontiersin.org/article/10.3389/fped.2019.00390/full

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