HIV-1 and SIV Predominantly Use CCR5 Expressed on a Precursor Population to Establish Infection in T Follicular Helper Cells

HIV-1 and SIV Predominantly Use CCR5 Expressed on a Precursor Population to Establish Infection in T Follicular Helper Cells

BackgroundT follicular helper (Tfh) cells are increasingly recognized as a major reservoir of HIV infection that will likely need to be addressed in approaches to curing HIV. However, Tfh express minimal CCR5, the major coreceptor for HIV-1, and the mechanism by which they are infected is unclear. W...

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Bibliographic Details
Main Authors: John Zaunders, Yin Xu, Chansavath Phetsouphanh, Kazuo Suzuki, Anu Aggrawal, Stephanie Graff-Dubois, Michael Roche, Michelle Bailey, Sheilajen Alcantara, Kieran Cashin, Rahuram Sivasubramaniam, Kersten K. Koelsch, Brigitte Autran, Richard Harvey, Paul R. Gorry, Arnaud Moris, David A. Cooper, Stuart Turville, Stephen J. Kent, Anthony D. Kelleher
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Immunology
Subjects:
HIV-1
CD4
T follicular helper cells
germinal center
CCR5
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00376/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00376/full

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