Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan sulfates (HS) syn...

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Bibliographic Details
Main Authors: Magali Macchi, Karine Magalon, Céline Zimmer, Elitsa Peeva, Bilal El Waly, Béatrice Brousse, Sarah Jaekel, Kay Grobe, Friedemann Kiefer, Anna Williams, Myriam Cayre, Pascale Durbec
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
multiple sclerosis
myelin
Ndst1
heparan sulfate
microglia
Human
Online Access:https://elifesciences.org/articles/51735

Internet

https://elifesciences.org/articles/51735

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