Analysis of Complement C3 Gene Reveals Susceptibility to Severe Preeclampsia

Analysis of Complement C3 Gene Reveals Susceptibility to Severe Preeclampsia

Preeclampsia (PE) is a common vascular disease of pregnancy with genetic predisposition. Dysregulation of the complement system has been implicated, but molecular mechanisms are incompletely understood. In this study, we determined the potential linkage of severe PE to the most central complement ge...

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Bibliographic Details
Main Authors: A. Inkeri Lokki, Tea Kaartokallio, Ville Holmberg, Päivi Onkamo, Lotta L. E. Koskinen, Päivi Saavalainen, Seppo Heinonen, Eero Kajantie, Juha Kere, Katja Kivinen, Anneli Pouta, Pia M. Villa, Leena Hiltunen, Hannele Laivuori, Seppo Meri
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
preeclampsia
complement
C3
association study
gene regulation
genetic risk
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00589/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00589/full

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