Intravitreal AAV-Delivery of Genetically Encoded Sensors Enabling Simultaneous Two-Photon Imaging and Electrophysiology of Optic Nerve Axons

Intravitreal AAV-Delivery of Genetically Encoded Sensors Enabling Simultaneous Two-Photon Imaging and Electrophysiology of Optic Nerve Axons

Myelination of axons by oligodendrocytes is a key feature of the remarkably fast operating CNS. Oligodendrocytes not only tune axonal conduction speed but are also suggested to maintain long-term axonal integrity by providing metabolic support to the axons they ensheath. However, how myelinating oli...

Full description

Bibliographic Details
Main Authors: Zoe J. Looser, Matthew J. P. Barrett, Johannes Hirrlinger, Bruno Weber, Aiman S. Saab
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
myelinated axons
intravitreal AAV injection
optic nerve recording
two-photon imaging
genetically encoded sensors
ATP-sensor ATeam1.03YEMK
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00377/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00377/full

Similar Items