Optimal VAsopressor TitraTION in patients 65 years and older (OVATION-65): protocol and statistical analysis plan for a randomised clinical trial

Optimal VAsopressor TitraTION in patients 65 years and older (OVATION-65): protocol and statistical analysis plan for a randomised clinical trial

Introduction Vasodilatory hypotension is common among intensive care unit (ICU) patients; vasopressors are considered standard of care. However, optimal mean arterial pressure (MAP) targets for vasopressor titration are unknown. The objective of the Optimal VAsopressor TitraTION in patients 65 years...

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Main Authors: Sangeeta Mehta, François Lauzier, Emmanuel Charbonney, Michaël Chasse, Marie-Claude Battista, Emilie Belley-Cote, Brian H Cuthbertson, Andreas Laupacis, Alexis F Turgeon, Frédérick D'Aragon, Tina Millen, Laveena Munshi, Sumesh Shah, Alexis Turgeon, David Bellemare, Eve Cloutier, Marjorie Daigle, Stéphanie Grenier, Gabrielle Guilbault, Sydney Miezitis, Rebecca Porteous, Irene Watpool, Karolina Walczak, Frédérick D’Aragon, Charles St-Arnaud, Elaine Carbonneau, Joannie Marchand, Marie-Hélène Masse, Fatna Benettaib, Dounia Boumahni, Marie-Ève Cantin, Ali Ghamraoui, Martine Lebrasseur, Maya Salame, Navjot Kaur, Nicole Marinoff, Guillaume Leblanc, Mary Elizabeth Wilcox, Ruxandra Pinto, Michael Mayette, Marc-André Leclair, Hector Quiroz Martinez, Brian Grondin-Beaudoin, Yannick Poulin, Andrew J E Seely, Édouard Botton, Dian Cohen, Neill K J Adhikari, Neill KJ Adhikari, Lauren Griffith, Scott Halpern, Louise Robert-Petit, Marie-Ève Thibault, François-Michel Boisvert, Lee Hwa Tai, Jean-Luc Parent, Xavier Roucou, Hector Quiroz-Martinez, Line Côté, Marilène Ladouceur, Noémie Turcotte, Andrew Seely, Andre Carlos Amaral, Wael Mohammed, Charles Francoeur, Olivier Costerousse, Isabelle St-Hilaire, Jeffrey Singh
Format: Article
Language:English
Published: BMJ Publishing Group 2020-11-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/10/11/e037947.full

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https://bmjopen.bmj.com/content/10/11/e037947.full

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