A replication-incompetent CD154/40L recombinant vaccinia virus induces direct and macrophage-mediated antitumor effects in vitro and in vivo

A replication-incompetent CD154/40L recombinant vaccinia virus induces direct and macrophage-mediated antitumor effects in vitro and in vivo

CD40 triggering may result in antitumor effects of potentially high clinical relevance. To gain insights important for patient selection and to identify adequate targeting techniques, we investigated CD40 expression in human cancer tissues and generated a replication-incompetent recombinant vaccinia...

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Bibliographic Details
Main Authors: Valeria Governa, Alvaro Brittoli, Valentina Mele, Maurizio Pinamonti, Luigi Terracciano, Simone Muenst, Giandomenica Iezzi, Giulio Cesare Spagnoli, Paul Zajac, Emanuele Trella
Format: Article
Language:English
Published: Taylor & Francis Group 2019-05-01
Series:OncoImmunology
Subjects:
cd40 pathway
recombinant vaccinia virus
macrophages
cellular immune responses
cancer immunotherapy
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1568162

Internet

http://dx.doi.org/10.1080/2162402X.2019.1568162

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