Cytochrome P450 and arachidonic acid bioactivation: molecular and functional properties of the arachidonate monooxygenase

The demonstration of in vivo arachidonic acid epoxidation and ω-hydroxylation established the cytochrome P450 epoxygenase and ω/ω–1 hydroxylase as formal metabolic pathways and as members of the arachidonate metabolic cascade. The characterization of the potent biological activities associated with...

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Bibliographic Details
Main Authors: Jorge H. Capdevila, John R. Falck, Raymond C. Harris
Format: Article
Language:English
Published: Elsevier 2000-02-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520320496