MIWI2 as an Effector of DNA Methylation and Gene Silencing in Embryonic Male Germ Cells

MIWI2 as an Effector of DNA Methylation and Gene Silencing in Embryonic Male Germ Cells

During the development of mammalian embryonic germ cells, global demethylation and de novo DNA methylation take place. In mouse embryonic germ cells, two PIWI family proteins, MILI and MIWI2, are essential for the de novo DNA methylation of retrotransposons, presumably through PIWI-interacting RNAs...

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Bibliographic Details
Main Authors: Kanako Kojima-Kita, Satomi Kuramochi-Miyagawa, Ippei Nagamori, Narumi Ogonuki, Atsuo Ogura, Hidetoshi Hasuwa, Takashi Akazawa, Norimitsu Inoue, Toru Nakano
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716310919

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http://www.sciencedirect.com/science/article/pii/S2211124716310919

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