Selanylimidazopyridine Prevents Lipopolysaccharide-Induced Depressive-Like Behavior in Mice by Targeting Neurotrophins and Inflammatory/Oxidative Mediators

Selanylimidazopyridine Prevents Lipopolysaccharide-Induced Depressive-Like Behavior in Mice by Targeting Neurotrophins and Inflammatory/Oxidative Mediators

Inasmuch, as the major depressive disorder (MDD) has been characterized as a heterogeneous disease as the inflammatory processes, neurotrophic factors’ dysfunction and oxidative/nitrosative stress are believed to play a vital role in its establishment. Organoselenium compounds stand out due to their...

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Bibliographic Details
Main Authors: Micaela Domingues, Angela M. Casaril, Paloma T. Birmann, Darling de A. Lourenço, Beatriz Vieira, Karine Begnini, Eder J. Lenardão, Tiago Collares, Fabiana K. Seixas, Lucielli Savegnago
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Neuroscience
Subjects:
major depressive disorder
lipopolysaccharide
imidazopyridines
selenium
depression
NFkB
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00486/full

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https://www.frontiersin.org/article/10.3389/fnins.2018.00486/full

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