Coordination between nucleotide excision repair and specialized polymerase DnaE2 action enables DNA damage survival in non-replicating bacteria

Coordination between nucleotide excision repair and specialized polymerase DnaE2 action enables DNA damage survival in non-replicating bacteria

Translesion synthesis (TLS) is a highly conserved mutagenic DNA lesion tolerance pathway, which employs specialized, low-fidelity DNA polymerases to synthesize across lesions. Current models suggest that activity of these polymerases is predominantly associated with ongoing replication, functioning...

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Bibliographic Details
Main Authors: Asha Mary Joseph, Saheli Daw, Ismath Sadhir, Anjana Badrinarayanan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
Caulobacter crescentus
DnaE2
dna repair
error-prone polymerases
fluorescence microscopy
nucleotide excision repair
Online Access:https://elifesciences.org/articles/67552

Internet

https://elifesciences.org/articles/67552

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