SMG1 identified as a regulator of Parkinson's disease-associated alpha-synuclein through siRNA screening.

SMG1 identified as a regulator of Parkinson's disease-associated alpha-synuclein through siRNA screening.

Synucleinopathies are a broad class of neurodegenerative disorders characterized by the presence of intracellular protein aggregates containing α-synuclein protein. The aggregated α-synuclein protein is hyperphosphorylated on serine 129 (S129) compared to the unaggregated form of the protein. While...

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Bibliographic Details
Main Authors: Adrienne Henderson-Smith, Donald Chow, Bessie Meechoovet, Meraj Aziz, Sandra A Jacobson, Holly A Shill, Marwan N Sabbagh, John N Caviness, Charles H Adler, Erika D Driver-Dunckley, Thomas G Beach, Hongwei Yin, Travis Dunckley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3813773?pdf=render

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http://europepmc.org/articles/PMC3813773?pdf=render

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