Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology

Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology

Amyloid-β (Aβ) deposition and tau-dependent pathology are key features of Alzheimer's disease (AD). However, to date, approaches aimed at counteracting these two pathogenic factors have produced only modest therapeutic outcomes. More effective therapies should therefore consider additional path...

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Bibliographic Details
Main Authors: Elisa Isopi, Alberto Granzotto, Carlo Corona, Manuela Bomba, Domenico Ciavardelli, Michele Curcio, Lorella M.T. Canzoniero, Riccardo Navarra, Rossano Lattanzio, Mauro Piantelli, Stefano L. Sensi
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Neurobiology of Disease
Subjects:
Pyruvate
Alzheimer's disease
3xTg-AD mice
Oxidative stress
Brain metabolism
Amyloid
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003581

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http://www.sciencedirect.com/science/article/pii/S0969996114003581

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