A Profound Basic Characterization of eIFs in Gliomas: Identifying eIF3I and 4H as Potential Novel Target Candidates in Glioma Therapy

A Profound Basic Characterization of eIFs in Gliomas: Identifying eIF3I and 4H as Potential Novel Target Candidates in Glioma Therapy

Glioblastoma (GBM) is an utterly devastating cerebral neoplasm and current therapies only marginally improve patients’ overall survival (OS). The PI3K/AKT/mTOR pathway participates in gliomagenesis through regulation of cell growth and proliferation. Since it is an upstream regulator of the rate-lim...

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Bibliographic Details
Main Authors: Stefanie Krassnig, Christina Wohlrab, Nicole Golob-Schwarzl, Andrea Raicht, Christoph Schatz, Anna Maria Birkl-Toeglhofer, Christina Skofler, Nadine Gantenbein, Marlene Leoni, Martin Asslaber, Stefan L. Leber, Kariem Mahdy-Ali, Gord von Campe, Marlene Mayer, Andrea Borenich, Serge Weis, Martin Benesch, Johannes Haybaeck
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
diffuse astrocytoma
anaplastic astrocytoma
glioblastoma
eukaryotic initiation factors (eIFs)
mTOR signaling
Online Access:https://www.mdpi.com/2072-6694/13/6/1482

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https://www.mdpi.com/2072-6694/13/6/1482

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