Early Islet Damage after Direct Exposure of Pig Islets to Blood: Has Humoral Immunity Been Underestimated?

Early Islet Damage after Direct Exposure of Pig Islets to Blood: Has Humoral Immunity Been Underestimated?

Currently, islet transplantation as a cell therapeutic option for type 1 diabetes occurs via islet injection into the portal vein. Direct contact between islets and blood is a pathophysiological “provocation” that results in the instant blood-mediated inflammatory reaction (IBMIR) and is associated...

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Bibliographic Details
Main Authors: Dirk J. Van Der Windt, Marco Marigliano, Jing He, Tatyana V. Votyakova, Gabriel J. Echeverri, Burcin Ekser, David Ayares, Fadi G. Lakkis, David K. C. Cooper, Massimo Trucco, Rita Bottino
Format: Article
Language:English
Published: SAGE Publishing 2012-08-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368912X653011

Internet

https://doi.org/10.3727/096368912X653011

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