Overexpression of ß-Arrestin1 in the Rostral Ventrolateral Medulla Downregulates Angiotensin Receptor and Lowers Blood Pressure in Hypertension

Overexpression of ß-Arrestin1 in the Rostral Ventrolateral Medulla Downregulates Angiotensin Receptor and Lowers Blood Pressure in Hypertension

Background: Hypertension is characterized by sympathetic overactivity, which is associated with an enhancement in angiotensin receptor type I (AT1R) in the rostral ventrolateral medulla (RVLM). β-arrestin1, a canonical scaffold protein, has been suggested to show a negative effect on G protein-coupl...

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Bibliographic Details
Main Authors: Jia-Cen Sun, Bing Liu, Ru-Wen Zhang, Pei-Lei Jiao, Xing Tan, Yang-Kai Wang, Wei-Zhong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Physiology
Subjects:
β-arrestin1
AT1R
hypertension
RVLM
sympathetic activity
NFκB
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00297/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2018.00297/full

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