Structural insight into the unique conformation of cystathionine β-synthase from Toxoplasma gondii

Structural insight into the unique conformation of cystathionine β-synthase from Toxoplasma gondii

Cysteine plays a major role in the redox homeostasis and antioxidative defense mechanisms of many parasites of the phylum Apicomplexa. Of relevance to human health is Toxoplasma gondii, the causative agent of toxoplasmosis. A major route of cysteine biosynthesis in this parasite is the reverse trans...

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Bibliographic Details
Main Authors: Carmen Fernández-Rodríguez, Iker Oyenarte, Carolina Conter, Irene González-Recio, Reyes Núñez-Franco, Claudia Gil-Pitarch, Iban Quintana, Gonzalo Jiménez-Osés, Paola Dominici, Maria Luz Martinez-Chantar, Alessandra Astegno, Luis Alfonso Martínez-Cruz
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Toxoplasmosis
Toxoplasma gondii
Reverse transsulfuration
Cystathionine β-synthase
Hydrogen sulfide
Homocysteine
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021002403

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http://www.sciencedirect.com/science/article/pii/S2001037021002403

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