The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi.

The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi.

The β1i, β2i and β5i immunoproteasome subunits have an important role in defining the repertoire of MHC class I-restricted epitopes. However, the impact of combined deficiency of the three immunoproteasome subunits in the development of protective immunity to intracellular pathogens has not been inv...

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Bibliographic Details
Main Authors: Jonatan Ersching, José R Vasconcelos, Camila P Ferreira, Braulia C Caetano, Alexandre V Machado, Oscar Bruna-Romero, Monique A Baron, Ludmila R P Ferreira, Edécio Cunha-Neto, Kenneth L Rock, Ricardo T Gazzinelli, Maurício M Rodrigues
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4851296?pdf=render

Internet

http://europepmc.org/articles/PMC4851296?pdf=render

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