Binding-Induced Conformational Changes Involved in Sliding Clamp PCNA and DNA Polymerase DPO4

Summary: Cooperation between DNA polymerases and DNA sliding clamp proteins is essential for DNA replication and repair. However, it is still challenging to clarify the binding mechanism and the movements of Y-family DNA polymerase IV (DPO4) on the proliferating cell nuclear antigen (PCNA) ring. Her...

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Bibliographic Details
Main Authors: Wen-Ting Chu, Zucai Suo, Jin Wang
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220303023