Core transcriptional regulatory circuits in prion diseases

Core transcriptional regulatory circuits in prion diseases

Abstract Complex diseases involve dynamic perturbations of pathophysiological processes during disease progression. Transcriptional programs underlying such perturbations are unknown in many diseases. Here, we present core transcriptional regulatory circuits underlying early and late perturbations i...

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Bibliographic Details
Main Authors: Taek-Kyun Kim, Inyoul Lee, Ji-Hoon Cho, Brenda Canine, Andrew Keller, Nathan D. Price, Daehee Hwang, George Carlson, Leroy Hood
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Molecular Brain
Subjects:
Murine PrP-prion disease
Gene expression
Transcriptional regulatory circuits
Feed-forward loops
Brain cell type
Online Access:https://doi.org/10.1186/s13041-020-0551-3

Internet

https://doi.org/10.1186/s13041-020-0551-3

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