Alpha1A-adrenergic receptor-directed autoimmunity induces left ventricular damage and diastolic dysfunction in rats.

Alpha1A-adrenergic receptor-directed autoimmunity induces left ventricular damage and diastolic dysfunction in rats.

<h4>Background</h4>Agonistic autoantibodies to the alpha(1)-adrenergic receptor occur in nearly half of patients with refractory hypertension; however, their relevance is uncertain.<h4>Methods/principal findings</h4>We immunized Lewis rats with the second extracellular-loop p...

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Main Authors: Katrin Wenzel, Gerd Wallukat, Fatimunnisa Qadri, Norbert Hubner, Herbert Schulz, Oliver Hummel, Florian Herse, Arnd Heuser, Robert Fischer, Harald Heidecke, Friedrich C Luft, Dominik N Muller, Rainer Dietz, Ralf Dechend
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20195525/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20195525/pdf/?tool=EBI

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