Inhibition of the Mitochondrial Glutamate Carrier SLC25A22 in Astrocytes Leads to Intracellular Glutamate Accumulation

Inhibition of the Mitochondrial Glutamate Carrier SLC25A22 in Astrocytes Leads to Intracellular Glutamate Accumulation

The solute carrier family 25 (SLC25) drives the import of a large diversity of metabolites into mitochondria, a key cellular structure involved in many metabolic functions. Mutations of the mitochondrial glutamate carrier SLC25A22 (also named GC1) have been identified in early epileptic encephalopat...

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Bibliographic Details
Main Authors: Emmanuelle Goubert, Yanina Mircheva, Francesco M. Lasorsa, Christophe Melon, Emanuela Profilo, Julie Sutera, Hélène Becq, Ferdinando Palmieri, Luigi Palmieri, Laurent Aniksztejn, Florence Molinari
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
mitochondrial glutamate carrier
glutamate transport
epilepsy
astrocytes
glutamate
ATP
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00149/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00149/full

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