An evolutionarily conserved glycine-tyrosine motif forms a folding core in outer membrane proteins.

An intimate interaction between a pair of amino acids, a tyrosine and glycine on neighboring β-strands, has been previously reported to be important for the structural stability of autotransporters. Here, we show that the conservation of this interacting pair extends to nearly all major families of...

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Bibliographic Details
Main Authors: Marcin Michalik, Marcella Orwick-Rydmark, Michael Habeck, Vikram Alva, Thomas Arnold, Dirk Linke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5542473?pdf=render