Possible pathophysiological roles of transglutaminase-catalyzed reactions in the pathogenesis of human neurodegenerative diseases

Possible pathophysiological roles of transglutaminase-catalyzed reactions in the pathogenesis of human neurodegenerative diseases

Transglutaminases (TG, E.C. 2.3.2.13) are related and ubiquitous enzymes that catalyze the cross linking of a glutaminyl residue of a protein/peptide substrate to a lysyl residue of a protein/peptide co-substrate. These enzymes are also capable of catalyzing other post-translational reactions import...

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Bibliographic Details
Main Authors: Enrica Serretiello, Martina Iannaccone, Federica Titta, Nicola G. Gatta, Vittorio Gentile
Format: Article
Language:English
Published: AIMS Press 2015-09-01
Series:AIMS Biophysics
Subjects:
transglutaminases
post-translational modifications of proteins
celiac disease
neurodegenerative diseases
transglutaminase inhibitors
cystamine
Online Access:http://www.aimspress.com/biophysics/article/416/fulltext.html

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http://www.aimspress.com/biophysics/article/416/fulltext.html

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