A new approach for heparin standardization: combination of scanning UV spectroscopy, nuclear magnetic resonance and principal component analysis.

A new approach for heparin standardization: combination of scanning UV spectroscopy, nuclear magnetic resonance and principal component analysis.

The year 2007 was marked by widespread adverse clinical responses to heparin use, leading to a global recall of potentially affected heparin batches in 2008. Several analytical methods have since been developed to detect impurities in heparin preparations; however, many are costly and dependent on i...

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Bibliographic Details
Main Authors: Marcelo A Lima, Timothy R Rudd, Eduardo H C de Farias, Lyvia F Ebner, Tarsis F Gesteira, Lauro M de Souza, Aline Mendes, Carolina R Córdula, João R M Martins, Debra Hoppensteadt, Jawed Fareed, Guilherme L Sassaki, Edwin A Yates, Ivarne L S Tersariol, Helena B Nader
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3022730?pdf=render

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http://europepmc.org/articles/PMC3022730?pdf=render

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