Detection of phenotype‐specific therapeutic vulnerabilities in breast cells using a CRISPR loss‐of‐function screen

Detection of phenotype‐specific therapeutic vulnerabilities in breast cells using a CRISPR loss‐of‐function screen

Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple‐negative breast cancer (TNBC). Here, we used isogenic human breast epithelial cell lines, D492...

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Bibliographic Details
Main Authors: Anna Barkovskaya, Craig M. Goodwin, Kotryna Seip, Bylgja Hilmarsdottir, Solveig Pettersen, Clint Stalnecker, Olav Engebraaten, Eirikur Briem, Channing J. Der, Siver A. Moestue, Thorarinn Gudjonsson, Gunhild M. Mælandsmo, Lina Prasmickaite
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Molecular Oncology
Subjects:
actionable targets
CRISPR knockout screen
epithelial–mesenchymal transition
phenotype plasticity
therapeutic vulnerabilities
triple‐negative breast cancer
Online Access:https://doi.org/10.1002/1878-0261.12951

Internet

https://doi.org/10.1002/1878-0261.12951

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