Bioavailability of an R-α-Lipoic Acid/γ-Cyclodextrin Complex in Healthy Volunteers

Bioavailability of an R-α-Lipoic Acid/γ-Cyclodextrin Complex in Healthy Volunteers

R-α-lipoic acid (R-LA) is a cofactor of mitochondrial enzymes and a very strong antioxidant. R-LA is available as a functional food ingredient but is unstable against heat or acid. Stabilized R-LA was prepared through complexation with γ-cyclodextrin (CD), yielding R-LA/CD. R-LA/CD was orally admini...

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Bibliographic Details
Main Authors: Naoko Ikuta, Hinako Okamoto, Takahiro Furune, Yukiko Uekaji, Keiji Terao, Ryota Uchida, Kosuke Iwamoto, Atsushi Miyajima, Takashi Hirota, Norihiro Sakamoto
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:International Journal of Molecular Sciences
Subjects:
R-α-lipoic acid
cyclodextrin
bioavailability
pharmacokinetics
healthy volunteers
clinical study
oral administration
Online Access:http://www.mdpi.com/1422-0067/17/6/949

Internet

http://www.mdpi.com/1422-0067/17/6/949

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