Extracellular Pgk1 enhances neurite outgrowth of motoneurons through Nogo66/NgR-independent targeting of NogoA

Extracellular Pgk1 enhances neurite outgrowth of motoneurons through Nogo66/NgR-independent targeting of NogoA

NogoA inhibits neurite outgrowth of motoneurons (NOM) through interaction with its receptors, Nogo66/NgR. Inhibition of Nogo receptors rescues NOM, but not to the extent exhibited by NogoA-knockout mice, suggesting the presence of other pathways. We found that NogoA-overexpressing muscle cells reduc...

Full description

Bibliographic Details
Main Authors: Cheng Yung Lin, Chia Lun Wu, Kok Zhi Lee, You Jei Chen, Po Hsiang Zhang, Chia Yu Chang, Horng Jyh Harn, Shinn Zong Lin, Huai Jen Tsai
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
muscle
motoneuron
NogoA
Pgk1
Online Access:https://elifesciences.org/articles/49175

Internet

https://elifesciences.org/articles/49175

Similar Items