Comprehensive Constitutional Genetic and Epigenetic Characterization of Lynch-Like Individuals

Comprehensive Constitutional Genetic and Epigenetic Characterization of Lynch-Like Individuals

The causal mechanism for cancer predisposition in Lynch-like syndrome (LLS) remains unknown. Our aim was to elucidate the constitutional basis of mismatch repair (MMR) deficiency in LLS patients throughout a comprehensive (epi)genetic analysis. One hundred and fifteen LLS patients harboring MMR-defi...

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Bibliographic Details
Main Authors: Estela Dámaso, Maribel González-Acosta, Gardenia Vargas-Parra, Matilde Navarro, Judith Balmaña, Teresa Ramon y Cajal, Noemí Tuset, Bryony A. Thompson, Fátima Marín, Anna Fernández, Carolina Gómez, Àngela Velasco, Ares Solanes, Sílvia Iglesias, Gisela Urgel, Consol López, Jesús del Valle, Olga Campos, Maria Santacana, Xavier Matias-Guiu, Conxi Lázaro, Laura Valle, Joan Brunet, Marta Pineda, Gabriel Capellá
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
Lynch syndrome
Lynch-like syndrome
variant of unknown significance
epimutation
mismatch repair
methylation
Online Access:https://www.mdpi.com/2072-6694/12/7/1799

Internet

https://www.mdpi.com/2072-6694/12/7/1799

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