Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis

Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis

Abstract Background Disruption of blood–brain barrier (BBB) and subsequent infiltration of auto-reactive T lymphocytes are major characteristics of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Kv1.3 channel blockers are demonstrated potential therapeutic effects on MS...

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Bibliographic Details
Main Authors: Jie Huang, Song Han, Qi Sun, Yipeng Zhao, Junchen Liu, Xiaolu Yuan, Wenqian Mao, Biwen Peng, Wanhong Liu, Jun Yin, Xiaohua He
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Cell & Bioscience
Subjects:
Kv1.3 channel blocker
Blood–brain barrier
Experimental autoimmune encephalomyelitis
Multiple sclerosis
IL-17
Online Access:http://link.springer.com/article/10.1186/s13578-017-0158-2

Internet

http://link.springer.com/article/10.1186/s13578-017-0158-2

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