A truncated protein product of the germline variant of the DUOX2 gene leads to adenomatous polyposis

A truncated protein product of the germline variant of the DUOX2 gene leads to adenomatous polyposis

Objective: In some patients with adenomatous polyposis, an identifiable pathogenic variant of known associated genes cannot be found. Researchers have studied this for decades; however, few new genes have been identified. Methods: Adenomatous polyposis coli (APC) negative polyposis patients were ide...

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Bibliographic Details
Main Authors: Mengyuan Yang, Yingxin Zhao, Yuwei Ding, Juan Wang, Yinuo Tan, Dong Xu, Ying Yuan
Format: Article
Language:English
Published: China Anti-Cancer Association 2021-02-01
Series:Cancer Biology & Medicine
Subjects:
adenomatous polyposis
duox2
whole-exome sequencing
endoplasmic reticulum retention
unfolded protein response
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/1782

Internet

http://www.cancerbiomed.org/index.php/cocr/article/view/1782

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