Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation

Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation

The human cytomegalovirus (HCMV) US12 family consists of ten sequentially arranged genes (US12-21) with poorly characterized function. We now identify novel natural killer (NK) cell evasion functions for four members: US12, US14, US18 and US20. Using a systematic multiplexed proteomics approach to q...

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Bibliographic Details
Main Authors: Ceri A Fielding, Michael P Weekes, Luis V Nobre, Eva Ruckova, Gavin S Wilkie, Joao A Paulo, Chiwen Chang, Nicolás M Suárez, James A Davies, Robin Antrobus, Richard J Stanton, Rebecca J Aicheler, Hester Nichols, Borek Vojtesek, John Trowsdale, Andrew J Davison, Steven P Gygi, Peter Tomasec, Paul J Lehner, Gavin W G Wilkinson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-02-01
Series:eLife
Subjects:
cytomegalovirus
human
immune evasion
natural killer cell
Online Access:https://elifesciences.org/articles/22206

Internet

https://elifesciences.org/articles/22206

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