L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells

L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells

The inhibitory effect of D and L-polynucleotides of a given length (40-50n) on the catalytic activity of DNA polymerase β isolated from chromatin cells of acute myeloid leukemia HL-60 was evaluated. The synthesized L enantiomer was found to have a higher inhibitory activity than the synthesized and...

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Bibliographic Details
Main Authors: S.V. Stovbun, A.S. Vedenkin, A.A. Bukhvostov, L.S. Koroleva, V.N. Silnikov, D.A. Kuznetsov
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
DNA Polymerase β
l-thymidine
HL-60
Leukemia
Polydeoxyribonucleotides
DNA Repair
Online Access:http://www.sciencedirect.com/science/article/pii/S240558082030145X

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http://www.sciencedirect.com/science/article/pii/S240558082030145X

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