Inhibition of the NKCC1/NF-κB Signaling Pathway Decreases Inflammation and Improves Brain Edema and Nerve Cell Apoptosis in an SBI Rat Model

Inhibition of the NKCC1/NF-κB Signaling Pathway Decreases Inflammation and Improves Brain Edema and Nerve Cell Apoptosis in an SBI Rat Model

Surgical brain injury (SBI) triggers microglia to release numerous inflammatory factors, leading to brain edema and neurological dysfunction. Reducing neuroinflammation and protecting the blood-brain barrier (BBB) are key factors to improve the neurological function and prognosis after SBI. Na+-K+-C...

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Bibliographic Details
Main Authors: Yating Gong, Muyao Wu, Jinchao Shen, Jiafeng Tang, Jie Li, Jianguo Xu, Baoqi Dang, Gang Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
surgical brain injury
NKCC1
NF-κB
neuroinflammation
brain edema
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.641993/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.641993/full

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