ICAM-1-LFA-1 Dependent CD8+ T-Lymphocyte Aggregation in Tumor Tissue Prevents Recirculation to Draining Lymph Nodes

ICAM-1-LFA-1 Dependent CD8+ T-Lymphocyte Aggregation in Tumor Tissue Prevents Recirculation to Draining Lymph Nodes

The quantity of T-lymphocytes reaching the draining lymph nodes from tumors is likely important to mount effective distant responses and for the establishment of long term systemic memory. Looking into mechanisms behind lymphocyte egress, we directed our attention to leukocyte adhesion mechanisms in...

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Bibliographic Details
Main Authors: Alba Yanguas, Saray Garasa, Álvaro Teijeira, Cristina Aubá, Ignacio Melero, Ana Rouzaut
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
draining lymph nodes
T-lymphocyte retention
homotypic cell-adhesion
ICAM-1
immune response
cancer immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02084/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02084/full

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