Modulation of polypeptide conformation through donor–acceptor transformation of side-chain hydrogen bonding ligands

Modulation of polypeptide conformation through donor–acceptor transformation of side-chain hydrogen bonding ligands

Hydrogen bonding plays a major role in determining the tridimensional structure of biopolymers. Here, the authors show that control over a polypeptide conformation can be achieved by altering the donor-acceptor properties of side-chain triazole units via protonation-deprotonation.

Bibliographic Details
Main Authors: Ziyuan Song, Rachael A. Mansbach, Hua He, Kuo-Chih Shih, Ryan Baumgartner, Nan Zheng, Xiaochu Ba, Yinzhao Huang, Deepak Mani, Yun Liu, Yao Lin, Mu-Ping Nieh, Andrew L. Ferguson, Lichen Yin, Jianjun Cheng
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00079-5

Internet

https://doi.org/10.1038/s41467-017-00079-5

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