Conditional ablation of MAPK7 expression in chondrocytes impairs endochondral bone formation in limbs and adaptation of chondrocytes to hypoxia

Conditional ablation of MAPK7 expression in chondrocytes impairs endochondral bone formation in limbs and adaptation of chondrocytes to hypoxia

Abstract Background Long bones of limbs are formed through endochondral bone formation, which depends on the coordinated development of growth plates. Our previous studies have demonstrated that dysfunction of mitogen-activated protein kinase 7 (MAPK7) can cause skeletal dysplasia. However, little i...

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Bibliographic Details
Main Authors: Xiaoming Yang, Dongmei Zhong, Wenjie Gao, Zhiheng Liao, Yuyu Chen, Shun Zhang, Hang Zhou, Peiqiang Su, Caixia Xu
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Cell & Bioscience
Subjects:
MAPK7
Chondrocytes
Growth plate development
Hypoxia
HIF1α
Online Access:http://link.springer.com/article/10.1186/s13578-020-00462-8

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http://link.springer.com/article/10.1186/s13578-020-00462-8

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