Conditional ablation of MAPK7 expression in chondrocytes impairs endochondral bone formation in limbs and adaptation of chondrocytes to hypoxia
Abstract Background Long bones of limbs are formed through endochondral bone formation, which depends on the coordinated development of growth plates. Our previous studies have demonstrated that dysfunction of mitogen-activated protein kinase 7 (MAPK7) can cause skeletal dysplasia. However, little i...
Main Authors: | Xiaoming Yang, Dongmei Zhong, Wenjie Gao, Zhiheng Liao, Yuyu Chen, Shun Zhang, Hang Zhou, Peiqiang Su, Caixia Xu |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-09-01
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Series: | Cell & Bioscience |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13578-020-00462-8 |
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