Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk

Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk

The Endoplasmic Reticulum acetylation machinery ensures proper quality control and disposal of newly folded proteins transiting the secretory pathway. Here, the authors show that this machinery acts as a metabolic regulator of acetyl-CoA homeostasis, impacting intracellular crosstalk.

Bibliographic Details
Main Authors: Inca A. Dieterich, Alexis J. Lawton, Yajing Peng, Qing Yu, Timothy W. Rhoads, Katherine A. Overmyer, Yusi Cui, Eric A. Armstrong, Porsha R. Howell, Maggie S. Burhans, Lingjun Li, John M. Denu, Joshua J. Coon, Rozalyn M. Anderson, Luigi Puglielli
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11945-9

Internet

https://doi.org/10.1038/s41467-019-11945-9

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