Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance

Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance

Tryptophan metabolites have been linked in observational studies with type 2 diabetes, cognitive disorders, inflammation and immune system regulation. A rate-limiting enzyme in tryptophan conversion is arylformamidase (Afmid), and a double knockout of this gene and thymidine kinase (Tk) has been rep...

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Bibliographic Details
Main Authors: Alison J. Hugill, Michelle E. Stewart, Marianne A. Yon, Fay Probert, I. Jane Cox, Tertius A. Hough, Cheryl L. Scudamore, Liz Bentley, Gary Wall, Sara E. Wells, Roger D. Cox
Format: Article
Language:English
Published: The Company of Biologists 2015-11-01
Series:Biology Open
Subjects:
Arylformamidase
Kynurenine
Tryptophan
Diabetes
Insulin secretion
Online Access:http://bio.biologists.org/content/4/11/1367

Internet

http://bio.biologists.org/content/4/11/1367

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