Reprogramming of regulatory network using expression uncovers sex-specific gene regulation in Drosophila

For many applications knowledge of context-specific gene regulatory networks (GRNs) is desirable, but their inference remains a challenge. Here, the authors introduce a method for construction of context-specific GRNs, and apply it to construct sex-specific Drosophila GRNs.

Bibliographic Details
Main Authors: Yijie Wang, Dong-Yeon Cho, Hangnoh Lee, Justin Fear, Brian Oliver, Teresa M. Przytycka
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06382-z