Elevated p16ink4a Expression in Human Labial Salivary Glands as a Potential Correlate of Cognitive Aging in Late Midlife.

Elevated p16ink4a Expression in Human Labial Salivary Glands as a Potential Correlate of Cognitive Aging in Late Midlife.

BACKGROUND:The cell-cycle inhibitor and tumor suppressor cyclin dependent kinase inhibitor, p16ink4a, is one of the two gene products of the ink4a/ARF (cdkn2a) locus on chromosome 9q21. Up-regulation of p16ink4a has been linked to cellular senescence, and findings from studies on different mammalian...

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Bibliographic Details
Main Authors: Christiane Elisabeth Sørensen, Katerina Tritsaris, Jesper Reibel, Martin Lauritzen, Erik Lykke Mortensen, Merete Osler, Anne Marie Lynge Pedersen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4814104?pdf=render

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http://europepmc.org/articles/PMC4814104?pdf=render

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