Involvement of the Eukaryote-Like Kinase-Phosphatase System and a Protein That Interacts with Penicillin-Binding Protein 5 in Emergence of Cephalosporin Resistance in Cephalosporin-Sensitive Class A Penicillin-Binding Protein Mutants in Enterococcus faecium

Involvement of the Eukaryote-Like Kinase-Phosphatase System and a Protein That Interacts with Penicillin-Binding Protein 5 in Emergence of Cephalosporin Resistance in Cephalosporin-Sensitive Class A Penicillin-Binding Protein Mutants in Enterococcus faecium

The intrinsic resistance of Enterococcus faecium to ceftriaxone and cefepime (here referred to as “cephalosporins”) is reliant on the presence of class A penicillin-binding proteins (Pbps) PbpF and PonA. Mutants lacking these Pbps exhibit cephalosporin susceptibility that is reversible by exposure t...

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Bibliographic Details
Main Authors: Charlene Desbonnet, Amelia Tait-Kamradt, Monica Garcia-Solache, Paul Dunman, Jeffrey Coleman, Michel Arthur, Louis B. Rice
Format: Article
Language:English
Published: American Society for Microbiology 2016-04-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/7/2/e02188-15

Internet

http://mbio.asm.org/cgi/content/full/7/2/e02188-15

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