Expanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressor

Expanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressor

p53 is a key protein that participates in cell-cycle control, and its malfunction can lead to cancer. This tumour suppressor protein has three main domains; the N-terminal transactivation domain, the CTD (C-terminal domain) and the core domain (p53C) that constitutes the sequence-specific DBD (DNA-b...

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Bibliographic Details
Main Authors: Claudia V. De Moura Gallo, Luciana P. Rangel, Yraima Cordeiro, Danielly C. F. Costa, Jerson L. Silva
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2013-07-01
Series:Bioscience Reports
Subjects:
amyloid
cancer
p53
prions
protein aggregation
protein misfolding
Online Access:http://www.bioscirep.org/bsr/033/e054/bsr033e054.htm

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http://www.bioscirep.org/bsr/033/e054/bsr033e054.htm

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